UJI EFEK SITOTOKSIK EKSTRAK METANOL DAUN MAHKOTA DEWA (Phaleriamacrocarpa (Schef) Boer) TERHADAP SEL KANKER PAYUDARA MCF7 DENGAN METODA MTT (Microtetrazolium) Assay

Amir, Hermansyah and Bambang Gonggo, Murcitro and Ahmad Shamsudin, Ahmad and Desy Fitrya, Syamsumir and Murni Nur Islamiah, Kassim (2016) UJI EFEK SITOTOKSIK EKSTRAK METANOL DAUN MAHKOTA DEWA (Phaleriamacrocarpa (Schef) Boer) TERHADAP SEL KANKER PAYUDARA MCF7 DENGAN METODA MTT (Microtetrazolium) Assay. Project Report. LPPM Universitas Bengkulu, Bengkulu.

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Abstract

This study aimed to investigate research about cytotoxicity correlation level of Phaleria macrocarpa (Scheff) Boerl also known as Mahkota Dewa leaves methanol extract against MCF-7 cell in vitro to investigate the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer.. Cytotoxicity properties of samples against MCF-7 breast cancer cell lines was performed by using the MTT Microtetrazolium assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that Phaleria macrocarpa (Scheff) Boerl.) leaves extracts showed cytoxicity activity against breast cancer MCF-7 cell lines which IC50 concentration showed at 15 µg/ml . Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = -0.37181, R2 = 0.138243). It could be effect of many different compounds in the Phaleria macrocarpa (Scheff) Boerl.) leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability. Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from Phaleria macrocarpa (Scheff) Boerl.) leaves methanol extracts have potential use as alternative drugs against breast cancer.

Item Type: Monograph (Project Report)
Subjects: L Education > L Education (General)
Divisions: Faculty of Education > Department of Chemistry Education
Depositing User: 001 Bambang Gonggo Murcitro
Date Deposited: 17 Mar 2017 03:55
Last Modified: 16 Jan 2018 06:39
URI: http://repository.unib.ac.id/id/eprint/11697

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