FORMULASI SEDIAAN PATCH TOPIKAL DARI EKSTRAK ETANOL 96% DAUN JAMBU BIJI (Psidium guajava L.)

This research aims to develop and test a topical patch preparation made
from 96% ethanol extract of guava leaves (Psidium guajava L.). Guava leaves were
chosen because they contain active compounds, such as tannins, triterpenoids,
flavonoids and saponins, which have been proven to have antibacterial, anti�inflammatory, antimutagenic, antimicrobial and antianalgesic effects. Guava leaf
extract was extracted using the maceration method using 96% ethanol solvent. The
extract obtained was then formulated into a topical patch preparation using HPMC
(Hydroxy Propyl Methyl Cellulose) and PVP (Polyvinylpyrrolidone) polymers. The
preparation evaluation includes organoleptics, thickness, weight uniformity,
folding resistance and pH. The results of this research show that in the organoleptic
test F1 and F2 produce better color and texture characteristics than F3, in the
folding resistance test F1 and F2 meet the ideal requirements for folding resistance
with a folding result of more than 300 while F3 does not meet the requirements, in
the weight uniformity test The standard deviation value obtained was 0.0025 in all
formulas which showed that the patch had a uniform weight, in the pH test the
formulations F1, F2, F3 were in the normal skin pH range with a range of 5.2-5.6
and in the thickness test results the patch had a thickness of 0.0025. uniform. This
research shows that the F2 patch preparation with a concentration of 5% guava
leaf extract produces the best physical properties compared to other formulas.
Meanwhile, F3 with a concentration of 7.5% guava leaf extract produced physical
properties of folding resistance that did not meet the requirements. This is because
the higher the extract will affect the quality of the physical properties of the patch
preparation.
Keywords: ethanol extract, Psidium guajava L., topical patches, HPMC polymer,
PVP